Modafinil Overview – Dosage, Side Effects, Research & More

What is Modafinil?


Modafinil (or provigil) is a drug originally intended for narcolepsy sufferers. Nootropic users have turned to modafinil as it is known to improve:


  • ability to focus in duration and intensity
  • analytic capabilities
  • memory recall and rentention
  • mood and well-being


Sports and fitness enthusiasts are also keen on modafinil supplementation. Provigil provides very capable increases in both aerobic and anaerobic performance enhancement. In one study Modafinil was found to drastically decrease fatigue levels.

Provigil is also used for treatment of ADHD (attention deficit hyperactivity disorder), depression, bi-polar disorder (the depression), cocaine dependence, and opiate dependence. Modafinil is only available in the United States via media prescription.


How does Modafinil work?


Modafinil intensifies specific neurotransmitters, most notably dopamine. Additionally, provigil affects histamine agonists, increasing them to keep high levels of wakefulness. Imagine taking an anti-histamine. They make you feel drowsy and out of focus. Modafinil works in the opposite way.


Side effects of Modafinil


Asparagus has a reputation for altering the smell and possibly color of one’s urine. Provigil has a similar effect. Studies have been inconclusive in determining the possibility of provigil addiction. However, logic would dictate a supplement affecting dopamine centers involves a possibility of habit forming behavior. Modafinil is a stimulant with positive cognitive and mood effects, and as such the possibility for abuse for must exist, yet caffeine may be similarly addictive.


Other side effects of Modafinil include:


  • increased sweats
  • tremors
  • pain in the back
  • headache
  • nausea
  • dry mouth or cotton mouth
  • anxiety
  • trouble sleeping

Modafinil Dosage


Evidence suggests 600mg is the suggested daily maximum dosage of provigil. Results vary and users are encouraged to find optimal dosage and dosage times. Most people take 100 – 200 mg once or twice daily. Be cognizant not to over supplement with Modafinil as there may be toxicity concerns.

You may also develop a tolerance to Modafinil over time so it is wise to cycle your usage.


Modafinil Research


Please review the following research papers for more information on provigil, effects, dosages, and general information.