Adrafinil vs Modafinil vs Armodafinil
Like Adrafinil and Modafinil, Armodafinil is a stimulant used to combat fatigue. Introduced in 2007, Armodafinil appears under brand names such as Nuvigil, Artvigil, and Waklert. It is purportedly more effective at lower doses than its relatives Adrafinil and Modafinil.
Armodafinil is an enantiopure drug. Enantiopure drugs contain only one of the enantiomers (spoken about earlier), R or S. The R enantiomer is longer acting and is most responsible for the effects of Modafinil specifically. Since the S enantiomer is not as strong, Armodafinil’s dosage is therefore lower. Most doses are 150mg compared to Modafinil’s 200mg standard dose.
Whilst the effects last for roughly the same time, Armodafinil takes longer to reach its peak than Modafinil, and therefore even longer than Adrafinil. This is simply because the S enantiomer reacts and leaves the body faster. Remember, Armodafinil does not have the S enantiomer, whereas Modafinil does. Adrafinil does, too, because Modafinil is a component within it. Because of this, users find that the effects of Armodafinil take longer to make themselves apparent – a potential disadvantage for prospective users.
So, how is Armodafinil processed? Dopamine is a compound existing as neurotransmitter within the body. It is also precursor of other substances including adrenaline. Armodafinil is an indirect dopamine receptor agonist. What this essentially means, then, is that Armodafinil provokes the dopamine levels in the body. This page offers further succinct information about Armodafinil, as well as Modafinil and Adrafinil.
Armodafinil is metabolized in much the similar way as Modafinil. It relies on amide hydrolysis primarily, and enzyme activity from by cytochrome P450 secondly. Amide Hydrolysis refers to the reaction with water of amides – a compound) (rxlist.com/nuvigil-drug/clinical-pharmacology).
As a consequence, this means that is does not rely as much on heavy enzyme activity in the liver. Adrafinil does. This presents further difference that may be considered by potential users. However, it is important to remember to stick to dosage guidance. If taken properly, and often cyclically, Adrafinil is no more threatening to the liver than Modafinil or Armodafinil.
Because Armodafinil, Modafinil and Adrafinil are all very similar in terms of effect, there is much discussion about which is the best. With regard to Modafinil and Armodafinil specifically, some may assume that because small dosages are needed for the latter that it is more efficient. However, it is important to remember individual sensitivity levels. Different drugs can have different reactions for different people. Potency is therefore not the only factor; the personal experience of using either Armodafinil or Modafinil is equally important. A trial and error approach may be necessary, but, of course, extensive research to find the best possible supplement for you is paramount.
In undertaking research, then, you may discover information that suits your needs. For example, here onnootriment.com/armodafinil-vs-modafinil, it is proposed that, unlike Modafinil, Armodafinil will not actually disturb your existing sleep patterns. Modafinil users might agree a good night’s sleep is difficult to achieve depending on the dosage.
Reddit user guitar1560 states that
I took 50mg two days in a row twice. Couldn’t sleep well the second night both times
Whereas SequenceConvenience writes
I’ve experienced pretty strong sleep changes while taking modafinil, but nothing that has been negative. I actually seem to need less sleep, at least in the sense that it is very easy for me to get out of bed the day after taking modafinil. Then again, I also don’t seem to have much in the way of dreams during those nights.
Armodafinil does not impact sleep pattern. However, with SequenceConvenience’s review, it is clear that some find this a positive effect of Modafinil while others, like guitar1560, may be disappointed.
Respective costs of the drugs might further influence your decision. KimberCT on Longe City tried both Armodafinil and Modafinil, but was swayed somewhat by the price of Nuvigil (the branded name of Armodafinil):
Currently taking 250mg armodafinil daily. To be honest, I kind of prefer modafinil. It seems to have a little more of a quick kick to it. Probably that isomer with a short half life peaking. Other than that, I can’t tell the difference between Nuvigil and modafinil (Sun Pharma). I’d probably have continued taking modafinil, but Cephalon has jacked the price since Nuvigil was FDA approved. With an Rx, Provigil is twice the price of Nuvigil. Their way of getting everyone onto Nuvigil before Provigil’s patent expires.
Adrafinil, meanwhile, can be obtained very cheaply online because it does not exist under a manufactured name. Nevertheless, many of these drugs are safe to use even if they lack a moniker like Provigil or Nuvigil. To stop concerns of the legitimacy of your purchased drug, always ask that your online manufacturer provides a COA (Certificate of Authenticity) on demand. This means that the substance batch has undergone a third-party laboratory analysis to ensure that your purchased drug matches its label and is not contaminated.
A common side-effect of Adrafinil is that the urine can smell different after ingestion of the drug. This is because one of Adrafinil’s metabolites contains a sulphur-based compound, and sulphur is strong smelling in itself.
However, these criticisms are not limited to Adrafinil alone and it should not sway potential users away from this particular drug. Modafinil has also been found to change the odor of urine. For example, PhysicsMaestro on Longe city queries:
I’ve been using modafinil (modalert) for about 8 months now, and regularly noticed a distinct smell of my urine whenever taking it. However, with this armodafinil, I don’t seem to notice it, which worries me a bit (i.e., not really what it states to be). Has anyone else noticed this difference between armodafinil and modafinil? I thought maybe the S-enantiomer could be metabolized and excreted quicker, thus resulting in an early onset smell, but I am just guessing.
The difference could easily be due to one of the excipients of the tablet, not the active ingredient. It’s also possible that only the S-enantiomer causes the smell, and of course, there’s the possibility that either these pills or the old ones didn’t actually contain modafinil. Sometimes they contain caffeine or dimethylamylamine or other stimulants, either mixed with modafinil or completely replacing it.
PhysicsMaestro thereafter concurrs:
I thought the odorous urine was ubiquitous to all variants of modafinil, resulting from its metabolites. But I guess the smell could be dependent on the enantiomer. I am willing to assume that whatever enzyme metabolizes modafinil to modafinil acid would leave its chirality intact. I don’t think it would be the excipients since the smell is so widely reported with different sources (and the modafinil has a sulfiyl group, so)
Nor does Armodafinil escape the urine issues. An anonymous writer on Erowid.org wrote:
Oh, and the pill tastes awful. Don’t let it get stuck in your mouth. And my pee starts to smell like it, too, but I get used to it
It is therefore important not to be selective of criticism based on what drug you have been swayed by. If you read that Modafinil is apparently “safer” because it does not rely on rampant enzyme activity, then do remember to include other issues such as cost-efficiency and, of course, other side-effects that might become more apparent than rare liver problems. These side-effects might include nausea, chest-pain or a faster heart rate (nhs.uk).
Adrafinil stands out as the most cost-effective, and, though it has been reported to alter urine odor, it is not alone. Modafinil, the more expensive, and Armodafinil, with a longer reaction time, also generate similar side-effects.
As well as reviews on specific effects of Adrafinil, Armodafinil or Modafinil, there are plenty of general overviews to be found around the internet. On Reddit, BitcoinOperatedGirl writes of her experience:
I tried the adrafinil first, starting with a low dose of 200mg one morning. I prepared a capsule and put it in a baggie next to my pillow before I went to sleep. When my alarm clock rang in the morning, I swallowed the capsule, silenced the alarm clock, and went back to sleep. I was expecting the stimulatory effect to eventually wake me up, as a caffeine pill would, but I ended up sleeping for two more hours. I felt a little disappointed after getting up and not feeling any stimulation, so I decided to add an extra 400mg to the mix.
The rest of the day, I was in a fairly good mood. I thought that I was maybe a little more energetic and motivated than usual. I was fairly productive and I worked out. The effect wasn’t what I expected, however. I’ve read people on here talking about feeling wired, and “laser beam focus”, but a whole 600mg of adrafinil felt nothing close to what I imagined (I guess I imagined it would feel like a mild dose of ritalin or something). On the upside, I experienced no substantial anxiety, whereas all the amphetamine-like drugs make me very uncomfortably anxious (I really can’t stand them, they feel disgusting to me). I didn’t really feel a crash and I went to bed at my normal hour.
I’m experimenting with adrafinil again today. I took 800mg this time. I was feeling particularly tired this morning (cripplingly tired, lethargic really). I definitely feel more energetic now. I’ve gotten some work done, I’m feeling the drive to write walls of text on reddit and I’m going to have a workout in a few minutes. I don’t expect to have any motivational issues today. Maybe I’ll even cook something fun. Only unfortunate side-effect seems to be a mild headache, but advil seems to be taking care of that.
I also tried armodafinil a week ago. Took a small 75mg dose in the morning. Same setup as with adrafinil. I also fell back to sleep for 2 hours. I felt pretty anxious that day and also got a headache. I can’t quite be sure the armodafinil is to blame but I suspect it is. Seems much more anxiety-inducing than adrafinil, which is unfortunate given that it seems adrafinil is worse for your liver. Armodafinil is probably just not for me.
Nezxon on LongeCity meanwhile states that:
I’m taking 75mg Adrafinil (Olmifon) twice daily and I haven’t experienced any side effects. I’d like to give Armodafinil a try, perhaps even safer in the long-term than Modafinil is.
These kinds of reviews certainly help to build a solid picture of each drug’s story. Undertaking research like this to decide on which drug is preferable to you is definitely something you should embark on before picking at random a supplement based on one review.